In this section:

Key points | Benefits and Harms | Comment


Key points

  • For GRADE evaluation of interventions for Trigeminal neuralgia, see table.
  • We found no evidence comparing gabapentin versus placebo/no treatment or other treatments covered in this review in people with trigeminal neuralgia.
  • Gabapentin does have support for use in treating other neuropathic pain conditions, particularly multiple sclerosis.

Benefits and harms


We found no systematic review or good-quality RCTs on the effects of gabapentin compared with placebo/no treatment or other listed interventions in the review in people with trigeminal neuralgia. For further information on harms of gabapentin, see harms of anti-epileptic drugs under Epilepsy.



As Clinical Evidence was unable to perform a second appraisal of results retrieved by the contributor's search, we may have missed studies that could affect our overall assessment of this intervention.

Clinical guide:

Although gabapentin has been shown to be effective in treating some neuropathic pain conditions,[38] particularly multiple sclerosis,[39] evidence for its use in trigeminal neuralgia is lacking. We did find one RCT that showed that gabapentin plus ropivacain (injected into trigger points) compared with gabapentin alone can improve pain and functional health status in trigeminal neuralgia with little or no side effects.[40]