Glycerol rhizolysis A percutaneous (requiring a needle inserted through the skin of the cheek) neurosurgical procedure that involves using a viscous alcohol called glycerol to damage the Gasserian ganglion and/or pre-ganglionic nerve route. The procedure stops the transmission of pain signals to the brain by causing selective chemical damage to the small unmyelinated and small myelinated pain fibres of the trigeminal nerve while ideally sparing the rest of the nerve fibres. This minimally invasive procedure is also known as percutaneous retrogasserian glycerol rhizolysis.